GENETICALLY ENGINEERED TRIPLE MAPT-MUTANT HUMAN-INDUCED PLURIPOTENT STEM CELLS (N279K, P301L, AND E10+16 MUTATIONS) EXHIBIT IMPAIRMENTS IN MITOCHONDRIAL BIOENERGETICS AND DYNAMICS

Pathological abnormalities in the tau protein give rise to a variety of neurodegenerative diseases, conjointly termed tauopathies.Several tau Anti-Aging mutations have been identified in the tau-encoding gene MAPT, affecting either the physical properties of tau or resulting in altered tau splicing.At early disease stages, mitochondrial dysfunction

Abstract The effects of thermal radiation and thermophoretic particles deposition (TPD) on the hybrid nanofluid (HNF) flow across a circling sphere have momentous roles in research and engineering.Such as electrical devices, projectiles, thermal conveyance, sheet production, renewable energy, and nuclear-powered plants.Therefore, the current study

Abstract Background Rho GTPase activating protein 9 (ARHGAP9) is expressed in various types of cancers and can inactivate Rho GTPases that mainly regulate cytoskeletal dynamics.However, the exact role of ARHGAP9 in acute myeloid leukemia (AML) has yet to be clarified.Methods We compared the transcriptional expression, prognosis, differentially expr

Prader-Willi Syndrome is the most common syndromic form of human obesity and is caused by the loss of function of several genes, including MAGEL2.Mice lacking Magel2 display increased weight gain with excess adiposity and other defects suggestive of hypothalamic deficiency.We demonstrate Magel2-null mice are insensitive to the anorexic effect of pe